The hypoglycemic activity of the ethanolic extract was evaluated in alloxan induced diabetic rats by single dose of 100mg/kg body weight. Antihyperglycemic activity of the extract was also evaluated at the same dose levels in alloxan monohydrate (80mg/kg s.c.) induced diabetic rats during a 15 days treatment period. Glibenclamide (4.5mg/kg) was used as the reference drug. Fasting blood glucose and sarum parameters triglycerides, total cholesterol, HDL cholesterol levels were measured acute oral toxicity of theNymphaea lotus rhizome extract was carried out in swiss albino mice.\r\nIn diabetic rats, ethanolic extract showed a significant (P<0.05) decreased the blood glucose level in a dose dependent manner during the 15 days of the treatment period. In the acute oral toxicity study, Nymphaea lotus showed no mortality. The present investigation shows that Nymphaea lotus rhizome has potential anti diabetic effects.
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